Antineutrophil cytoplasmic antibodies
- Description: ANCAs comprise antibodies against specific cytoplasmic antigens
- c-ANCA (Proteinase-3 antibody)
- Granulomatosis with polyangiitis: ∼ 90% of patients are ANCA positive (mostly c-ANCA).
- Rarely in microscopic polyangiitis, Eosinophilic granulomatosis with polyangiitis, infective endocarditis
- p-ANCA (Myeloperoxidase antibody)
- Microscopic polyangiitis: ∼ 70% of patients are ANCA positive (mostly p-ANCA).
- Eosinophilic granulomatosis with polyangiitis: ∼ 50% of patients are ANCA positive (both c-ANCA and p-ANCA).
- Atypical p-ANCA